Publications

Non-equilibrium structural dynamics of supercoiled DNA plasmids exhibit asymmetrical relaxation.

Authors:
Cynthia Shaheen | Cameron Hastie | Kimberly Metera | Shane Scott | Zhi Zhang | Sitong Chen | Gracia Gu | Lisa Weber | Brian Munsky | Fedor Kouzine | David Levens | Craig Benham | Sabrina R. Leslie
Year of Publication:
2021

Simultaneous, single-particle measurements of size and loading give new insights into the structure of drug-delivery nanoparticles.

Authors:
Albert Kamanzi | Yifei Gu | Radin Tahvildari | Zachary Friedenberger | Xingqi Zhu | Romain Berti | Marty Kurylowicz | Dominik Witzigmann | Jayesh A. Kulkarni | Jerry Leung | John Andersson | Andreas Dahlin | Fredrik Hook | Mark Sutton | Pieter R. Cullis | Sabrina R. Leslie
Year of Publication:
2021

Single-molecule imaging of the biophysics of molecular interactions with precision and control, in cell-like conditions, and without tethers.

Authors:
Sabrina Leslie | Daniel Berard | Albert Kamanzi | Kimberly Metera | Shane Scott | Cynthia Shaheen | Marjan Shayegan | Radin Tahvildari | Zhiyue Zhang
Year of Publication:
2019

Single-cell analysis for drug development using Convex Lens-Induced Confinement (CLiC) imaging.

Authors:
Ndeye Khady Thiombane | Nicolas Coutin | Daniel J. Berard | Radin Tahvildari | Sabrina R. Leslie | Corey Nislow
Year of Publication:
2019

Single-molecule visualization of the effects of ionic strength and crowding on structure-mediaed interactions in supercoiled DNA molecules.

Authors:
Shane Scott | Cynthia Shaheen | Brendon McGuiness | Kimberly Metera | Fedor Kouzine | David Levens | Craig J Benham | Sabrina Leslie*
Year of Publication:
2019

Probing inhomogeneous diffusion in the microenvironments of phase-separated polymers under confinement.

Authors:
Marjan Shayegan | Radin Tahvildari | Lydia Kisley | Kimberly Metera | Stephan W. Michnick | Sabrina R. Leslie*
Year of Publication:
2019

Miniaturized flow cell with pneumatically-actuated vertical nanoconfinement for single-molecule imaging and manipulation.

Authors:
Daniel J. Berard | Sabrina R. Leslie*
Year of Publication:
2018

Visualizing Structure-mediated Interactions in Supercoiled DNA Molecules

Authors:
Shane Scott | Zhi Ming Xu | Fedor Kouzine | Daniel J. Berard | Cynthia Shaheen | Laura Saunders | Barbara Gravel | Alexander Hofkirchner | Catherine Leroux | Jill Laurin | David Levens | Craig Benham | Sabrina R. Leslie*
Year of Publication:
2018

Biological Confinement Physics: Squeezing New Information out of Complex Macromolecules

Authors:
Sabrina R. Leslie* | Albert Kamanzi | Daniel Berard | Marjan Shayegan | Gilead Henkin | Jason Leith | Shane Scott | Francis Stabile
Year of Publication:
2017

Spin-induced Spooling of Macromolecules

Authors:
Tyler Shendruck* | Dave Sean* | Daniel Berard* | Julian Wolf | Justin Dragoman | Sophie Battat | Gary Slater | Sabrina R. Leslie*
Year of Publication:
2017

Manipulating and visualizing molecular interactions in customized nanoscale spaces

Authors:
Gilead Henkin | Daniel Berard | Francis Stable | Marjan Shayegan | Jason S. Leith | Sabrina R. Leslie*
Year of Publication:
2016

Directly Measuring the Free Energy of a Polymer in Slit-Like Confinement from the Odijk to the Bulk Regime

Authors:
Jason S. Leith* | Albert Kamanzi* | Dave Sean | Daniel Berard | Andrew Guthrie | Christopher M.J. McFaul | Gary Slater | Hendrick de Haan* | Sabrina R. Leslie*
Year of Publication:
2016

Parallelized Cytoindentation Using Convex Micropatterned Surfaces

Authors:
Bojing Jia | Tse-Luen Wee | Daniel J. Berard | Adiel Mallik | David Juncker | Claire M. Brown* | Sabrina R. Leslie*
Year of Publication:
2016

Formatting and Ligating Biopolymers using Adjustable Nanotopographies

Authors:
Daniel Berard* | Marjan Shayegan* | François Michaud | Gilead Henkin | Shane Scott | Sabrina R. Leslie*
Year of Publication:
2016

Continuous Confinement Fluidics: Getting Lots of Molecules in Small Spaces

Authors:
Jalal Ahamed | Sara Mahshid | Daniel Berard | François Michaud | Rob Sladek | Walter Reisner* | Sabrina R. Leslie*
Year of Publication:
2016

Development of a Platform for Single Cell Genomics Using Convex Lens- Induced Confinement

Authors:
Sara Mahshid | Mohammed Jalal Ahamed | Daniel Berard | Susan Amin | Rob Sladek | Sabrina R. Leslie* | Walter Reisner*
Year of Publication:
2015

Open-frame System for Single-Molecule Microscopy

Authors:
Adriel Arsenault | Jason Leith | Gil Henkin | Christopher McFaul | Matthew Tarling | R. Talbot | Daniel Berard | François Michaud | Shane Scott | Sabrina Leslie*
Year of Publication:
2015

Convex lens-induced nanoscale templating

Authors:
Daniel Berard | François Michaud | Sara Mahshid | Mohammed Jalal Ahamed | Christopher McFaul | Jason Leith | Pierre Berube | Rob Sladek | Walter Reisner | Sabrina R. Leslie*
Year of Publication:
2014

Precision Platform for Convex Lens-Induced Confinement Microscopy

Authors:
Daniel Berard | Christopher McFaul | Jason Leith | Adriel Arsenault | François Michaud | Sabrina Leslie*
Year of Publication:
2013

Single-molecule fluorescence imaging of processive myosin with enhanced background suppression using linear Zero Mode Waveguides (ZMW) and Convex Lens-induced Confinement (CLiC)

Authors:
Mary Williard Elting | Sabrina R. Leslie* | L. Stirling Churchman | Jonas Korlach | Chris McFaul | Jason S. Leith | Michael J. Levene | Adam E. Cohen | James A. Spudich
Year of Publication:
2013