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Plotkin Research Group

Principal Researcher

Steven Plotkin Steve Plotkin Protein misfolding and neurodegenerative disease; Molecular-genetic basis of multicellularity

Post Doctoral Researchers

Luke McAlary Molecular interplay of liquid-liquid phase separation and pathogenic aggregation of TDP43 in ALS
Xubiao Peng Xubiao Peng

Energy landscape theory for protein misfolding: applications to ALS and cancer

Graduate Researchers

Vibudh Agrawal Algorithmic discovery of genetic regulatory elements
Pranav Garg Models of cell differentiation and development
Tiam Heydari Mechanisms of germ cell specification in early metazoans

Undergraduate Researchers

Christopher Chang Genetics of stem cell niches in C-elegans
Johnathan Hoggarth TDP-43 liquid-liquid phase separation and stress granule formation in ALS
Neil Cashman

Publications:

Li L, Guest W, Huang A, Plotkin SS, Cashman N, "Immunological mimicry of PrPc-PrPSc interactions: Antibody-induced PrP misfolding" Protein Engineering, Design and Selection 22(8):523-529 (2009).

Guest W, Cashman N, Plotkin SS, "Electrostatics in the Stability and Misfolding of the Prion Protein: Salt Bridges, Self-Energy, and Solvation" Biochem. Cell Biol 88, 371–381 (2010)

Guest W, Plotkin SS, Cashman NR, "Toward A Mechanism of Prion Misfolding and Structural Models of PrPSc: Current Knowledge and Future Directions", J Toxicol Env Health Part A, 74:154–160 (2011)[4]

Grad LI, Guest W, Yanai A, Pokrishevsky E, O’Neill MA, Gibbs E, Semenchenko V, Yousefi M, Wishart DS, Plotkin SS, Cashman NR, "Intermolecular transmission of superoxide dismutase 1 misfolding in living cells" Proc. Natl. Acad. Sci, 108, 16398–16403 (2011)

Guest W, Cashman NR, Plotkin SS, "A Theory for the Anisotropic and Inhomogeneous Dielectric Properties of Proteins" Phys. Chem. Chem. Phys., 13 (13), 6286 - 6295 (2011)

Grad LI, et al "Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms" Proc. Natl. Acad. Sci. USA 111, 3620-3625 (2014)

Silverman JM, Gibbs E, Martens KM, Balducci C, Wang J, Yousefi M, Peng X, Lamour G, Cowan CM, Forloni G, Hsiung GR, Plotkin SS, Wellington CL and Cashman NR "A Neutralizing Epitope For Toxic And Propagating Amyloid-beta Oligomers," Submitted June 2016.

PI on project grants:

PrioNet Canada: “Prion-Like Propagated Misfolding of SOD1 in ALS Pathogenesis”

“Prion Protein Conversion in disease: The “Demiglobule” Hypothesis”

Co-inventor:

"C-terminal epitopes in Amyloid beta and conformationally-selective antibodies thereto" Inventors: Plotkin SS and Cashman NR, Provisional Patent 62/352,346. Filed June 20, 2016.

"N-terminal epitopes in Amyloid beta and conformationally-selective antibodies thereto" Inventors: Plotkin SS and Cashman NR, Provisional Patent 62/331,925. Filed May 11, 2016.

"Epitopes in Amyloid beta and antibodies thereto" Inventors: Steven S Plotkin and Neil R Cashman, Provisional Patent 62/309,765., Filed: March 17, 2016

"Amyloid beta epitopes and antibodies thereto" Inventors: Steven S. Plotkin and Neil Cashman, Provisional Patent 62/289893, Filed: February 1, 2016

"Methods and Systems for Predicting Misfolded Protein Epitopes" Inventors: Neil R. Cashman, Steven S. Plotkin, William C. Guest, Application #: 12/574,637, Publication #: US 2010/0233176 A1, Patent Filing date: Oct 6, 2009, Pub. Date: Sep. 16, 2010.

"Methods and Systems for Determining Localized Dielectric Properties of a Molecule" Inventors: William C. Guest, Neil R. Cashman, Steven S. Plotkin, Application #: 12/952,140 Publication #: US 2011/0125478 A1, Patent Filing date: Nov 22, 2010, Pub. Date: May 26, 2011.

Andriy Kovalenko

PI on project grants:

“Immunological Lead Towards Characterization of Toxic Oligomers for Therapeutic Targeting in Neurodegenerative Diseases”

“Targeting Prion-Like Propagated Misfolding of SOD1 for ALS Immunotherapy”
Joerg Rottler

Publications:

Morriss-Andrews A, Rottler J, Plotkin SS, "A Systematically Coarse-grained Model for DNA, and its Predictions for Persistence Length, Stacking, Twist, and Chirality" J Chem Phys 132, 035105 (2010)

Habibi M, Rottler J, and Plotkin SS "As Simple as Possible but not Simpler: Exploring the Fidelity of Coarse-Grained Protein Models for Simulated Force Spectroscopy", PLoS Comput Biol 12(11): e1005211. doi:10.1371/journal. pcbi.1005211

Habibi M, Rottler J, and Plotkin SS "The unfolding mechanism of monomeric mutant SOD1 by simulated force spectroscopy", Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, https://doi.org/10.1016/j.bbapap.2017.06.009

Habibi M, Plotkin SS, and Rottler J "Soft vibrational modes predict force-induced protein unfolding mechanisms" Submitted

Cecilia Clementi

Publications:

Clementi C, Plotkin SS, "The Effects of Non-native Interactions on Protein Folding Rates: Theory and Simulation" Prot. Sci. 13, 1750-1765 (2004)

Waterfall at UBC Memorial Japanese Garden Pond at UBC Japanese Memorial Garden
The above photos are from the UBC Japanese Memorial Garden on campus.
To see more, please visit the photo gallery under "Fun".
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Header
UBC Logo Steven Samuel Plotkin, Associate Professor at UBC
Aerial shot of Vancouver
Home  |  Research  |  Publications  |  Prospective Students  |  Teaching  |  Contact  | Physics  |  BioVEC  |  Fun