Welcome to the website for the Plotkin Research Group!
We do research at the interface of biology and physics.
Our interests currently focus on the molecular-genetic study of the evolution of cellular differentiation, to the study of dynamics, disorder, and phase separation in the theory of protein folding, misfolding, and aggregation. Please see our Research Page for more details!
Plotkin Group News:
- McAlary L, Plotkin SS, Cashman NR "Emerging developments in targeting proteotoxicity in neurodegenerative diseases" CNS Drugs (submitted)
- DuVal MG, McAlary L, Habibi M, Garg P, Sher M, Cashman NR, Allison WT, and Plotkin SS "Physical Properties of Novel Aggressive and Beneficial SOD1 Mutants Predict Phenotypes Consistent with ALS" (posted on bioRxiv)
- Peng X, Gibbs, E, Silverman JM, Cashman NR, and Plotkin SS "A Method for Systematically Screening Drug Candidates Using Multiple Criteria with Unknown Predictive Importance"
- Pataer A, Ozpolat, B, Shao R, Kabil, N, Lin S, Cashman NR, Samuel CE, Plotkin SS, Correa A, Majidi M, Fang B, Roth JA, Behrens C, Vaporciyan A, Wistuba I, Hung MC, Swisher S "PKR contributes to lysosome function, prevents misfolded protein release and is a target for cancer therapy"
We are grateful to the Canadian Institutes of Health Research, Alberta Innovates and the Alberta Prion Research Institute, and Westgrid/Compute Canada for supporting our research.