First Name
Carl
Last Name
Hansen
Position
Associate Professor
Office Room
NCE 307
Lab Room
NCE 322,323
Tel (Office)
(604) 827-3229
Tel (Lab)
(604) 827-3547
Email
chansen@phas.ubc.ca
Research Groups

Students Wanted
N/A



Bachelor's Degree
UBC, 2000, Engineering Physics / Electrical Engineering / Honors Math

Master's Degree
Caltech, 2004, Applied Physics

Doctoral Degree
Caltech, 2004, Applied Physics

Citizenship
Canadian

Hobbies and Interests

Running, Cycling, triathlon


Research Area
Biophysics

Research Field
Microsystems Technology for Biological Applications

Research Topics
Single-Cell Analysis, Molecular Diagnostics, genomics

Selected Publications
  1. Heyries, K.A. & C.L. Hansen. “Parylene C coating for improved soft lithography-based device production.” LAB ON A CHIP (2011) Accepted for publication.
  2. Sekulovic, S., M. Gasparetto, V. Lecault, C.A. Hoesli, D.G. Kent, P. Rosten, A. Wan, C. Brookes, C.L. Hansen, J.M. Piret, C. Smith, C.J. Eaves, and R.K. Humphries. "Ontogeny stage-independent and high-level clonal expansion in-vitro of mouse hematopoietic stem cells stimulated by an engineered NUP98-HOX fusion transcription factor." BLOOD (2011) Aug 24. [Epub ahead of print]. 
  3. White, A., M. VanInsberghe, O.I. Petriv, M. Hamidi, M.A. Marra, J.M. Piret, S. Aparicio, and C.L. Hansen. “High-Throughput Microfluidic RT-qPCR of Single Cells”. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (2011) Aug 23;108(34):13999-4004. 
  4. Heyries, K.A., C. Tropini, M. VanInsberghe, O.I. Petriv, C. Hugesman, A. Singhal, K. Leung, C.L. Hansen. “Megapixel Digital PCR”. NATURE METHODS (2011) Jul 3;8(8):649-51. 
  5. Lecault, V., M. VanInsberghe, S. Sekulovic, T. McLaughlin, A. Jarandehei, M.M. Miller, F. Taghipour, D. Falconnet, A.K. White, D.G. Kent, M.R. Copley, C.J. Eaves, R.K. Humphries, J.M. Piret, C.L. Hansen. “High-Throughput Analysis of Single Hematopoietic Stem Cell Proliferation in Perfusion Microfluidic Cell Culture Arrays”, NATURE METHODS (2011) May 22. 8(7):581-6. 
  6. Petriv, O.I., C.L. Hansen, R.K. Humphries, F. Kuchenbauer. “Probing the complexity of miRNA expression across hematopoiesis”. CELL CYCLE (2011) 10(1): 15443-8. 
  7. Liu, Q., B. Larsen, M. Ricicova, S. Orlicky, H. Tekotte, X. Tang, K. Craig, A. Quiring, T. Le Bihan, C.L. Hansen, F. Sicheri, M. Tyers. “SCFCdc4 enables mating type switching in yeast by CDK-dependent elimination of the Ash1 transcriptional repressor”. MOLECULAR AND CELLULAR BIOLOGY (2011) 31(3):584-9. 
  8. Falconnet, D., Niemisto, A., Taylor, R.J., Ricicova, M., Galitski, T., Shmulevich, I., Hansen, C.L., "High-Throughput Tracking of Single Yeast Cells in a Microfluidic Imaging Matrix". LAB ON A CHIP (2011) 11(3):466-7. 
  9. Starczynowski, D.T., F. Kuchenbauer, J. Wegrzyn, A. Rouhi, O.I. Petriv, C.L. Hansen, R.K. Humphries, A. Karsan. “MicroRNA-146a disrupts hematopoietic differentiation and survival”, EXPERIMENTAL HEMATOLOGY (2011) 39(2):167-178.e4. 
  10. Singhal, A., Haynes, C., Hansen, C.L., “Microfluidic Measurement of Antibody-Antigen Binding Kinetics from Low Abundance Samples and Single Cells”. ANALYTICAL CHEMISTRY (2010) 82 (20):8671-9.
  11. Petriv, O.I., F. Kuchenbauer, A. D. Delaney, V. Lecault, A.K. White, D. Kent, L. Marmolejo, M. Heuser, T. Berg, M. Copley, J. Ruschmann, S. Sekulovic, F. Antignano, E. Kuroda, V. Ho, C. Benz, T. Halim, V. Giambra, G. Krystal, C.J.F. Takei, A.P. Weng, C. Eaves, J. Piret, M.A. Marra, R.K. Humphries, C.L. Hansen. “Comprehensive microRNA Expression Profiling of the Hematopoietic Hierarchy Using High-Throughput Microfluidic qPCR Arrays”. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (2010) 107, 15443-15448.
  12. Huft, J., D.J. Da Costa, D. Walker, C.L. Hansen. “Three-dimensional large-scale microfluidic integration by laser ablation of interlayer connections”. LAB ON A CHIP (2010) 10, 2358-2365 
  13. Lam, M.H.C., M.A. Homenuke, C.A. Michal, & C.L. Hansen. “Sub-nanoliter nuclear magnetic resonance coils fabricated with multilayer soft lithography”. JOURNAL OF MICROMECHANICS AND MICROENGINEERING (2009) 19 No 9, Article #095001.
  14. Garanov, A.I., M. Cook, M. Ricicova, G. Ben-Ari, C. Gonzalez, C.L. Hansen, M. Tyers, A. Amon. “The rate of cell growth is governed by cell cycle stage”. GENES AND DEVELOPMENT (2009) 23: 1408-1422. 
  15. R.J. Taylor, D. Falconnet, A. Niemisto, S.A. Famsey, S. Prinz, I. Shmulevich, T. Galitski, and C. L. Hansen. "Dynamic analysis of MAPK signaling using a high-throughput microfluidic single-cell imaging platform". (2009) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 106, 3758 – 3763. 
  16. A.H. Diercks, A. Ozinsky, C.L. Hansen, J.M. Spotts, D.J. Rodriguez, and A. Aderem. "A microfluidic device for multiplexed protein detection in nano-liter volumes". (2009) ANALYTICAL BIOCHEMISTRY. 386 (1) 30-5. 
  17. F. Kuchenbauer, R.D. Morin, B. Argiropoulos, O.I. Petriv, M. Griffith, M. Heuser, E. Yung, J. Piper, A. Delaney, A. Prabhu, Y. Zhao, H. McDonald, T. Zeng, M. Hirst, C.L. Hansen, M.A. Marra, and R.K. Humphries. "In-depth characterization of the microRNA transcriptome in a leukemia progression model". (2008) GENOME RESEARCH (11) 1787-97. 
  18. Hansen, C., Leung, K. & Mousavi, P. "Chipping in to microfluidics". PHYSICS WORLD 20, 24-29 (2007).
  19. Lau, B. T. C., Baitz, C. A., Dong, X. P., Hansen, C. L., "A Complete Microfluidic Screening Platform for Rational Protein Crystallization", (2007) JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129, 454-455 
  20. Hansen, C.L., S. Classen, J.M. Berger, S.R. Quake. "A Microfluidic Device for Kinetic Optimization of Protein Crystallization and In Situ Structure Determination". (2006) JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 128.10 (February 2006): 3142 - 3143. 
  21. Anderson M.J., Hansen C.L., Quake S.R., "Phase Knowledge Enables Rational Screens for Protein Crystallization", (2006) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 103, 16746–16751 
  22. Hansen, C.L., Classen S., Berger J.M., Quake, S.R. "A Microfluidic Device for Kinetic Optimization of Protein Crystallization and In Situ Structure Determination", (2006) JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128 (10) : 3142 - 3143. (PDF)
    Featured in Science (PDF) and Nature Methods 
  23. M.J. Anderson, C.L. Hansen, and S.R. Quake. "The use of microfluidic devices towards protein crystallography". (2005) BIOPHYSICAL JOURNAL, Vol. 88 No. 1, 55A.
  24. Balagadde, F.K., You, L., Hansen, C.L., Arnold, F.H. & Quake, S.R. "Long-term Monitoring of Bacteria Undergoing Programmed Oscillations in a Microchemostat", (2005) SCIENCE, 309: 137-140.
  25. Hansen, C.L., Sommer, M. O. & Quake, S. R., "Systematic investigation of protein phase behavior with a microfluidic formulator". (2004) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101, 14431-14436. 
  26. Liu, J., Hansen, C. & Quake, S. R. (2003), "Solving the "world-to-chip" interface problem with a microfluidic matrix". ANALYTICAL CHEMISTRY 75, 4718-4723. 
  27. Hansen, C. L. & Quake, S. R. (2003), "Microfluidics in structural biology: smaller, faster … better". CURRENT OPINION IN STRUCTURAL BIOLOGY 13, 538-544. 
  28. Hansen, C. L., Skordalakes, E., Berger, J. M. & Quake, S. R., "A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion", (2002) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99, 16531-16536.