High-sensitivity coherent anti-Stokes Raman scattering microscopy with two tightly synchronized picosecond lasers RID C-3312-2011

TitleHigh-sensitivity coherent anti-Stokes Raman scattering microscopy with two tightly synchronized picosecond lasers RID C-3312-2011
Publication TypeJournal Article
Year of Publication2002
AuthorsPotma, EO, D. J. Jones, JX Cheng, XS Xie, and J. Ye
JournalOptics Letters
Volume27
Issue13
Pagination1168 - 1170
Date Published2002/07/01/
ISBN Number0146-9592
AbstractWe demonstrate a significant improvement in signal-to-noise ratio in coherent anti-Stokes Raman scattering (CARS) spectroscopy/microscopy, using two highly synchronized picosecond Ti:sapphire lasers. A temporal jitter between the pulse trains from the two independent commercial lasers is reduced from a few picoseconds to similar to21 fs. maintained over several hours. The tight synchronization brings the fluctuation of the CARS signal down to the shot-noise limit. leading to enhanced CARS vibrational images of living cells and polymer beads. (C) 2002 Optical Society of America.
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